A new hypothesis for how sex steroid hormones regulate bone mass
نویسندگان
چکیده
منابع مشابه
Non-genomic actions of sex steroid hormones.
Steroid hormone receptors have been traditionally considered to act via the regulation of transcriptional processes, involving nuclear translocation and binding to specific response elements, and ultimately leading to regulation of gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called 'non-ge...
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of the 3H-label in their experiments is associated with the cells is difficult to interpret. Although some of the experiments by Hammes et al. are consistent with their “bound steroid” hypothesis (see, for example, Figure 2A), others are not (for example, see Figures 2B and 2C). At a concentration of 1 nM DHT plus 1 nM SHBG, 50% of the steroid exists in the free form. One nanomole of DHTSHBG an...
متن کاملSex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver.
CYP2E1 is of paramount toxicological significance because it metabolically activates a large number of low-molecular-weight toxicants and carcinogens. In this context, factors that interfere with Cyp2e1 regulation may critically affect xenobiotic toxicity and carcinogenicity. The aim of this study was to investigate the role of female steroid hormones in the regulation of CYP2E1, as estrogens a...
متن کاملChanges in sex hormones and calcium regulating hormones with reference to bone mass associated with aging.
Measurement of bone mineral content (BMC), intestinal 47Ca absorption, and calcium regulating hormones and sex steroids in serum were performed on 32 healthy aged subjects and 26 control young subjects. In BMC, there was a progressive fall after age 40, with the rate of decrease being greater in women than in men. A significant correlation was observed between BMC and testosterone in the men an...
متن کاملThe correlation of anandamide with gonadotrophin and sex steroid hormones during the menstrual cycle
Objective(s): The purpose of this study was to investigate the change in plasma anandamide (AEA) levels throughout the normal menstrual cycle, and to analyze the relationship among AEA, sex steroids and gonadotrophins. Materials and Methods: The patients were fertile women with normal menstrual cycle, proposed to get in vitro fertilization (IVF) treatment due to oviduct obstruction or male infe...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2003
ISSN: 0021-9738
DOI: 10.1172/jci200318812